DNA Methylation Test with Personalized Health Insights

DNA Methylation & MTHFR Test

$418Kit plus Health Intelligence. One-time price.
1
Over 300 DNA variants analyzed

Learn your methylation status with the Gene Food DNA methylation test. Tests for AHCY, CBS, COMT, MTHFR, MTR, MTRR, and more genetic markers.

  • CLIA-Certified Lab
  • 300+ DNA Variants Analyzed
  • Data Never Sold

What You'll Learn

  • Your MTHFR status

    Your results for the common C677T and A1298C variants.

  • The full methylation panel

    15 SNPs across AHCY, CBS, COMT, DPEP1, MTR, MTRR, MTHFR, and SLC19A1.

  • Folate and B12 metabolism

    How your genes affect the way you process these nutrients.

  • Your personalized diet type

    Which of 20 diet types fits your genes, with macro targets.

  • Gene Food AI assistant

    Ask questions about your results and get meal plans and grocery lists built around them.

Methylation and Homocysteine Report

Learn your genetic predispositions for the methylation pathway

DNA methylation is a complex biochemical process that has been in the news lately, with health influencers like Gary Brecka publicizing the role methylation plays in health. Abnormal DNA methylation related to chronic stress has been linked to an increased risk of cardiovascular disease, and nutrients like folate play a role in the proper functioning of this important pathway. The Gene Food methylation panel looks at several key genetic markers involved in the methylation process so users can get a clear picture of how this pathway functions.

Explore Plans
Methylation
Intermediate risk
Gene
Variant
Result
MTHFR
rs1801133
C/T
MTR
rs1805087
A/A
MTRR
rs1801394
A/G
COMT
rs4680
G/G

Based on a review of your SNPs in the methylation cycle, you carry some risk variants for methylation function.

Illustrative report example

John O'Connor, founder of Gene Food
A note from our founder

Methylation and MTHFR are where I got started with nutrigenomics almost a decade ago. It's a fascinating topic, and a widely misunderstood one. We've been reporting on it since 2018, and we've run methylation panels for thousands of customers since.

If you're comparing options, I think our testing holds up well against the alternatives. You also get our proprietary Gene Food diet type and AI assistant, which no one else offers.

We'd be honored to have you in the community.

John O'Connor, Founder
Reviews

Satisfied customers

Amazing
★★★★★

“Gene Food completely changed the way I approach nutrition. Meal plan is easy to follow, results were ready in 15 minutes, and I no longer crave sweets.”

JL
Jamila Lynn
Hunter Gatherer
The best DNA diet app
★★★★★

“I’ve tried several other companies, including InsiderTracker and DNAfit; if your primary concern is diet then I would absolutely recommend Gene Food as the best of the bunch.”

AP
Alexis Philippou
Urban Grazer
Carbs are GOOD
★★★★★

“Once I went back to carbs (based on the Okinawa diet) and quit the whole 30/paleo diet as well as any attempts at Keto or low-carb, my weight stopped rising, and actually started to go down (and I didn’t even follow the Okinawa diet very strictly, and did no caloric restriction)!”

KC
Kat C.
Okinawan
Best health decision of my adult life
★★★★★

“Acquiring a custom nutrition plan from Gene Food was the single best health decision of my adult life. I frequent the Gene Food blog & the Gene Food podcast. John O’Connor and Dr. Aaron Gardner are focused on providing individuals with the very best science based information today. I believe their individualized approach, not the “one size fits all” seen frequently, is the future of optimizing health and wellness.”

BB
Bethny Brown-Avila
Wayoan
Diet Types

Twenty unique diet types, where will you fit?

Gene Food uses a proprietary algorithm to divide customers into one of twenty unique diet types based on dietary fat metabolism, ApoE status, carbohydrate response, histamine, and ability to digest lactose. Where will you fit?

West Angeleno

Healthy fats from whole foods, whole grains, fresh over leftovers, and two plant-based days a week.

Low carb, high fat

Wayoan

Plant-based and low-fat. Meat as a condiment, most dairy out, calories from complex carbs, wild fish for protein.

Macrobiotic template

Lean Machine

Whole grains and plant fats, no dairy, protein mostly from plants with wild fish to hold muscle.

Whole grains, plant fats

Villager

Low-fat, whole-food and plant-based. No oil, fresh over aged foods, calories from complex carbohydrates.

Low glycemic, low fat

Okinawan

Fiber-rich complex carbs make up most calories; saturated fat kept low, no seed oils, animal protein as a condiment.

High carb, very low fat

Vegetarian

Plants first with fish in the rotation. Complex carbs for calories, olive oil only, fresh foods to keep histamine down.

High carb, low fat

Urban Grazer

Robust genes, few restrictions. Whole grains, healthy fats, plant proteins, no dairy or processed meat.

Balanced, few limits

Hunter Gatherer

Omega-3s over saturated fat, low-glycemic carbs, mostly plant protein, and fresh foods to keep histamine in check.

Low glycemic, higher protein

Find your diet type
Purchase GeneFood

Unlock your diet type and methylation profile

Discover the diet type that fits your DNA — plus clear insight into how your genes impact methylation, a key process for energy and overall health. Our CLIA-certified test gives you a personalized nutrition plan and targeted methylation guidance rooted in your unique genetics, including the AHCY, COMT, MTR, MTRR, and MTHFR genes.

Gene Food DNA test collection kit

Frequently asked questions

The methylation test is updated regularly as our research team evaluates new SNPs. The panel currently looks at 15 SNPs and the following genes: AHCY, CBS, COMT, DPEP1, MTR, MTRR, MTHFR, SLC19A1

Methylation is needed to create DNA and RNA and regulate gene expression, it literally turns on and off genes. A disrupted DNA methylation pathway can cause inflammation and has been linked to various diseases, including cancer, neurological disorders, and cardiovascular diseases. Understanding DNA methylation can provide insights into disease mechanisms and how to craft a personalized approach to health and nutrition.

In our view, understanding methylation status from a genetic perspective is most helpful as a tool for personalizing cardiovascular health. Some individuals who “undermethylate” may benefit from nutritional support, and certain supplements, like methylfolate.

From a genetic standpoint, yes. The one-carbon pathway is a universal pathway required for the synthesis of nucleic acids and for the remethylation of homocysteine. Folate is a vital nutrient in the one-carbon pathway as it facilitates the transport of methyl groups needed for DNA methylation and homocysteine remethylation. High levels of homocysteine have long been linked to the development of heart disease and cognitive impairment. There’s now a general acceptance that it’s important to keep homocysteine levels in check. And, as homocysteine plays a role in DNA methylation, factors affecting methylation processes can also affect homocysteine status.

The methylation test is included in the Health Intelligence premium tier, which also includes the Gene Food diet type and new health reports published each month. We test for 15 SNPs shown to impact DNA methylation so users get a comprehensive picture of their status for this important pathway.

Like all our tests, the DNA methylation test is a simple cheek swab test. A self-addressed return envelope is included with the test kit, as are detailed instructions for taking the test. The swab sample is sent to our CLIA-certified laboratory in Houston, where the sequencing occurs.