Histamine Intolerance Genetic Test | DAO Enzyme - Gene Food

Histamine Score + Gene Food Diet Type

$239One-time price. No subscription.
1
Included with Basic

Genetics plays a role in histamine intolerance. Learn your status for the key genes involved in the histamine metabolism pathway with the Gene Food histamine scoring panel.

  • CLIA-Certified Lab
  • Personalized DNA insights
  • Data Never Sold

What You'll Learn

  • Tests for genes linked to histamine intolerance
  • Data is 100% confidential and secure
  • Personalized nutrition recommendations
  • Learn your Gene Food diet type
Histamine intolerance report

Learn how your body metabolizes histamine

Would you benefit from a low histamine diet? Some individuals cannot efficiently metabolize histamine in the intestine, resulting in sensitivity to normal or even low histamine levels in food. Research has estimated that it affects 1–3% of the population, a percentage that is likely to increase as more knowledge and diagnostic tools for histamine intolerance become available. According to the American Journal of Clinical Nutrition, genetics can play a role in developing histamine intolerance. Some of us produce less diamine oxidase (DA) than others, which is the enzyme that clears extra-cellular histamine from the gut. The Gene Food histamine test uses polygenic risk scoring to evaluate genetic predispositions towards histamine intolerance, with an emphasis placed on the AOC1 gene and histamine clearance from the digestive tract. Histamine metabolism plays an important role in the algorithm we use at Gene Food to divide customers into one of twenty proprietary diet types.

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Histamine intolerance report example
Illustrative report example, not your personal results.
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“Once I went back to carbs (based on the Okinawa diet) and quit the whole 30/paleo diet as well as any attempts at Keto or low-carb, my weight stopped rising, and actually started to go down (and I didn’t even follow the Okinawa diet very strictly, and did no caloric restriction)!”

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Find out how your body actually handles carbs

Low-carb works for some people and backfires for others. In the PREDICT-1 trial, genetics accounted for nearly half of the variation in how much blood sugar rose two hours after a meal. Our CLIA-certified test scores your carbohydrate response across multiple validated SNPs, matches you to one of 20 diet types, and turns it into a plan: the carbs that suit you, the ones to limit, and a two-week meal plan built around them.

Gene Food DNA test collection kit

Frequently asked questions

The histamine pathway can be a source of GI and digestive issues for some individuals, and genetic testing can shine a spotlight on an issue that may have been overlooked. Diamine oxidase is an enzyme that is difficult to measure in a traditional lab setting, so genetic markers can be a valuable tool. It is said that histamine intolerance starts in the gut, which means that anyone looking in earnest for the cause of chronic digestive problems can benefit from understanding their genetic predisposition for this important pathway.

As with all our tests, the histamine test is a simple cheek swab test. Our histamine scoring system uses polygenic risk scoring to evaluate the genetic markers linked to decreased histamine metabolism. This means we evaluate several SNPs relevant to histamine metabolism and assign a score based on the number of “mutations” each user carries in this pathway. The primary focus of the testing is to evaluate genetic markers associated with histamine clearance from the digestive tract and the diamine oxidase enzyme.

Yes, histamine scoring plays a role in the Gene Food scoring algorithm we use to assign diet types. Some of our diet types, like Villager and Hunter Gatherer, recommend keeping a closer eye on dietary histamine.